The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1

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• 作者：Sabrina Chriett ; Ouafa Zerzaihi ; Hubert Vidal ; Luciano Pirola ; ^{luciano.pirola@univ-lyon1.fr}
• 关键词：Histone acetylation ; Insulin signalling ; HDACi ; Sodium butyrate ; L6 myotubes
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：224-232
• 全文大小：1338 K
• 卷排序：439

文摘

Sodium butyrate (NaBut) is a histone deacetylase (HDAC) inhibitor. NaBut ameliorates the insulin-resistant phenotype, induced by prolonged exposure to palmitate in L6 muscle cells. NaBut improves insulin-induced phosphorylation of PKB and MAPK in insulin-resistant cells. NaBut causes histone H3 hyperacetylation on chromatin in proximity of the Irs1 transcriptional start site. NaBut promotes insulin responsiveness in L6 myotubes under conditions of lipid-induced insulin resistance.