The nucleotide analogue 3-deazaadenosine prevents neointima-formation after balloon injury
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- 作者：Florian H. Seeger ; Wolfram Hess ; Daniel Sedding ; Gunter Becker ; Ralf Kinscherf ; Ruediger C. Braun-Dullaeus ; Christiane Viedt ; Jö ; rg Kreuzer
- 关键词：c3Ado ; 3-deazaadenosine ; Restenosis ; Neointima ; Balloon injury ; SMC ; Proliferation ; Rats
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2009
- 出版时间：23 January 2009
- 年：2009
- 卷：378
- 期：4
- 页码：826-831
- 全文大小：827 K
文摘
We have recently shown that 3-deazaadenosine (c3Ado) inhibits atherogenesis in mice. We studied whether its anti-inflammatory capacity would also affect neointima-formation after balloon injury. Sprague Dawley rats underwent balloon angioplasty. C3Ado was administered orally, starting 5 days prior to the balloon injury and continued for 2 weeks. Fourteen days after balloon injury the intima/media ratio in the c3Ado-treated group was reduced by 67 % (p < 0.001) and luminal stenosis by 50 % (p < 0.001). Neointimal cellular density was decreased by 25 % (p < 0.001) and the induction of c-Jun and ki67 was markedly lower. The reduction of the intima/media ratio was still observed 3 months after balloon injury. Furthermore, a c3Ado-dependent inhibition of PDGF-mediated ERK-activation and proliferation could be demonstrated.
Short-term administration of C3Ado inhibits neointima-formation in rats for at least 3 months after injury. The present findings implicate that c3Ado may be useful as an inhibitor of restenosis-formation after balloon angioplasty in humans.