Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides
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- 作者：Michal Tichy ; Radek Pohl ; Eva Tlou?t¡¯ov¨¢ ; Jan Weber ; Gina Bahador ; Yu-Jen Lee ; Michal Hocek
- 关键词：Nucleosides ; Pyrimido[4 ; 5-b]indoles ; Suzuki and Stille cross-coupling ; Anti-dengue virus activity
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2013
- 出版时间：1 September, 2013
- 年：2013
- 卷：21
- 期：17
- 页码：5362-5372
- 全文大小：953 K
文摘
Two series of new 4-aminopyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 5 or 6 have been prepared by Suzuki or Stille cross-coupling reactions employing X-Phos ligand with (het)arylboronic acids or stannanes. A series of 4-substituted nucleosides has been also prepared by Pd-catalyzed cross-couplings or nucleophilic substitution. Some of these compounds displayed moderate antiviral activities against HCV and dengue viruses.