Chaperone-like protein HYPK and its interacting partners augment autophagy
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- 作者：Kamalika Roy Choudhury1 ; 2 ; withkamalika@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sudha Bucha1 ; sudhabucha@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shounak Baksi3 ; 5 ; shounakbaksi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Debashis Mukhopadhyay3 ; debashis.mukhopadhyay@saha.ac.in" class="auth_mail" title="E-mail the corresponding author ; Nitai P. Bhattacharyya ; 4 ; nitai.bhattacharyya@gmail.com" class="auth_mail" title="E-mail the corresponding author ; nitai_sinp@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HYPK ; Autophagy ; Cell survival ; Huntington&rsquo ; s disease ; Apoptosis
- 刊名：European Journal of Cell Biology
- 出版年：2016
- 出版时间：June-July 2016
- 年：2016
- 卷：95
- 期：6-7
- 页码：182-194
- 全文大小：2977 K
文摘
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HTT-interacting chaperone HYPK has 54 primary and 1026 secondary interactors.
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Ten primary and 91 secondary HYPK-interactors potentially involved in autophagy.
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HYPK augments expressions of autophagy markers in mouse straital cell lines.
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HYPK recovers autophagy in HD condition induced by HTT exon1 with pathogenic polyQ.
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Autophagy induction by HYPK might help to clear toxic misfolded HTT aggregates.