Prenatal vitamin D status and risk of psychotic experiences at age 18 years¡ªa longitudinal birth cohort

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• 作者：Sarah Sullivan ; Andrew Wills ; Debbie Lawlor ; John McGrath ; Stanley Zammit
• 关键词：25-Hydroxyvitamin D ; Pre-natal ; Psychotic experiences ; Birth cohort ; ALSPAC
• 刊名：Schizophrenia Research
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：148
• 期：1-3
• 页码：87-92
• 全文大小：393 K

文摘

Background

Low early life vitamin D status is associated with an increased risk of schizophrenia and psychotic experiences. Here we examine if maternal pregnancy vitamin D concentrations are associated with offspring psychotic experiences as young adults.

Methods

A community sample of 2047 participants was investigated. Maternal prenatal 25 hydroxyvitamin D (25(OH)D) concentrations were assessed with tandem mass spectroscopy. Psychotic experiences were assessed at age 18 years using a semi-structured clinical interview.

Results

177 cohort members reported suspected or definite psychotic experiences, There was no evidence of an association between maternal 25(OH)D concentrations as quartiles (p = 0.85 hypothesis test of general association versus no association across the quartiles) or as a continuous variable (p = 0.89) versus experience of suspected and definite psychotic experiences at 18 years. Within the cohort, only 29 subjects met criteria for a psychotic disorder at age 18. Based on this sample, there was no significant association between maternal 25(OH)D and psychotic disorder at 18 years.

Discussion

Maternal vitamin D levels were not associated with risk of psychotic experiences nor psychotic disorders in this birth cohort.