Total synthesis of Z-isomer of phomolide B

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• 作者：Debendra K. Mohapatra ; D. Prabhakar Reddy ; Uttam Dash ; J.S. Yadav
• 关键词：Phomolide B ; Decanolides ; Sharpless asymmetric epoxidation ; Yamaguchi esterification ; Ring-closing metathesis
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：5 January 2011
• 年：2011
• 卷：52
• 期：1
• 页码：151-154
• 全文大小：460 K

文摘

We have achieved the synthesis of Z-isomer of phomolide B during our investigation toward the effect of protecting group on the outcome of ring-closing metathesis reaction. The other key reactions involved are cis-selective partial hydrogenation, Sharpless asymmetric epoxidation, Yamaguchi esterification, and following 12 longest linear sequence with 18.5 % overall yield starting from a known intermediate 20.