Gold(III)-catalyzed direct nucleophilic substitution of propargylic alcohols

详细信息    查看全文

• 作者：Marie Georgy ; Valé ; rie Boucard ; Olivier Debleds ; Christophe Dal Zotto ; Jean-Marc Campagne
• 刊名：Tetrahedron
• 出版年：2009
• 出版时间：28 February 2009
• 年：2009
• 卷：65
• 期：9
• 页码：1758-1766
• 全文大小：580 K

文摘

Gold-catalyzed nucleophilic substitution of propargylic alcohols with various nucleophiles (allylsilane, electron-rich aromatics, alcohols, thiols, hydrides, 1,3-dicarbonyl derivatives, sulfonamides) is described under very mild conditions (room temperature in dichloromethane). Preliminary mechanistic investigations suggest a mechanism through a carbocation intermediate. Nucleophilic substitutions on allylic and benzylic alcohols are also described.