- 作者：Anand Shah ; M.D. ; M.P.H.&lowast ; ; Jason A. Efstathiou ; M.D. ; D.Phil.?/sup> ; Jonathan J. Paly ; B.S.?/sup> ; Scott D. Halpern ; M.D. ; Ph.D. ; M.B.E.&dagger ; ; &Dagger ; ; § ; ; ¶ ; ; Deborah W. Bruner ; Ph.D. ; R.N.&lowast ; &lowast ; ; John P. Christodouleas ; M.D. ; M.P.H.&lowast ; ; John J. Coen ; M.D.?/sup> ; Curtiland Deville Jr. ; M.D.&lowast ; ; Neha Vapiwala ; M.D.&lowast ; ; William U. Shipley ; M.D.?/sup> ; Anthony L. Zietman ; M.D.?/sup> ; Stephen M. Hahn ; M.D.&lowast ; ; Justin E. Bekelman ; M.D.&lowast ; ; ¶ ; ; bekelman@uphs.upenn.edu
- 关键词：Prostate cancer ; Intensity-modulated radiotherapy ; Proton beam therapy ; Randomized controlled trial
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2012
- 出版时间：1 May, 2012
- 年：2012
- 卷：83
- 期：1
- 页码：e13-e19
- 全文大小：434 K
Purpose
To investigate patients?willingness to participate (WTP) in a randomized controlled trial (RCT) comparing intensity-modulated radiotherapy (IMRT) with proton beam therapy (PBT) for prostate cancer (PCa).Methods and Materials
We undertook a qualitative research study in which we prospectively enrolled patients with clinically localized PCa. We used purposive sampling to ensure a diverse sample based on age, race, travel distance, and physician. Patients participated in a semi-structured interview in which they reviewed a description of a hypothetical RCT, were asked open-ended and focused follow-up questions regarding their motivations for and concerns about enrollment, and completed a questionnaire assessing characteristics such as demographics and prior knowledge of IMRT or PBT. Patients?stated WTP was assessed using a 6-point Likert scale.
Results
Forty-six eligible patients (33 white, 13 black) were enrolled from the practices of eight physicians. We identified 21 factors that impacted patients?WTP, which largely centered on five major themes: altruism/desire to compare treatments, randomization, deference to physician opinion, financial incentives, and time demands/scheduling. Most patients (27 of 46, 59 % ) stated they would either ¡°definitely?or ¡°probably?participate. Seventeen percent (8 of 46) stated they would ¡°definitely not?or ¡°probably not?enroll, most of whom (6 of 8) preferred PBT before their physician visit.
Conclusions
A substantial proportion of patients indicated high WTP in a RCT comparing IMRT and PBT for PCa.