Enrolling African-American and Latino patients with asthma in comparative effectiveness research: Lessons learned from 8 patient-centered studies

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• 作者：C. Bradley Kramer ; MPA^a ; Lisa LeRoy ; MBA ; PhD^b ; Sara Donahue ; DrPH ; MPH^b ; Andrea J. Apter ; MD^c ; Tyra Bryant-Stephens ; MD^d ; John P. Elder ; MD^e ; Winifred J. Hamilton ; MD^f ; Jerry A. Krishnan ; MD ; PhD^g ; Deborah Q. Shelef ; MPH^h ; James W. Stout ; MD ; MPHⁱ ; Kaharu Sumino ; MD ; MPH^j ; Stephen J. Teach ; MD ; MPH^k ; Alex D. Federman ; MD ; MPH^l ; ^{alex.federman@mssm.edu}
• 关键词：Comparative effectiveness research ; patient-centered outcomes research ; asthma ; study recruitment ; vulnerable populations
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：138
• 期：6
• 页码：1600-1607
• 全文大小：206 K
• 卷排序：138

文摘

African-American and Latino patients are often difficult to recruit for asthma studies. This challenge is a barrier to improving asthma care and outcomes for these populations.ObjectivesWe sought to examine the recruitment experiences of 8 asthma comparative effectiveness studies that specifically targeted African-American and Latino patients, and identify the solutions they developed to improve recruitment.MethodsCase report methodology was used to gather and evaluate information on study design, recruitment procedures and outcomes from study protocols and annual reports, and in-depth interviews with each research team. Data were analyzed for themes, commonalities, and differences.ResultsThere were 4 domains of recruitment challenges: individual participant, institutional, research team, and study intervention. Participants had competing demands for time and some did not believe they had asthma. Institutional challenges included organizational policies governing monetary incentives and staff hiring. Research team challenges included ongoing training needs of recruitment staff, and intervention designs often were unappealing to participants because of inconveniences. Teams identified a host of strategies to address these challenges, most importantly engagement of patients and other stakeholders in study design and troubleshooting, and flexibility in data collection and intervention application to meet the varied needs of patients.ConclusionsAsthma researchers may have greater success with recruitment by addressing uncertainty among patients about asthma diagnosis, engaging stakeholders in all aspects of study design and implementation, and maximizing flexibility of study and intervention protocols. However, even with such efforts, engagement of African-American and Latino patients in asthma research may remain low. Greater investment in research on engaging these populations in asthma research may ultimately be needed to improve their asthma care and outcomes.