Serotonergic perturbations in dystonia disorders—a systematic review
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- 作者：M. Smita ; m.smit03@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; A.L. Bartelsa ; b ; a.l.bartels@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; M. van Faassenc ; h.j.r.van.faassen@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; A. Kuipera ; a.kuiper@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; K.E. Niezen- Koningc ; k.e.niezen.koning01@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; I.P. Kemac ; i.p.kema@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; R.A. Dierckxd ; r.a.dierckx@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; T.J. de Koninge ; t.j.de.koning@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; M.A. Tijssena ; m.a.j.de.koning-tijssen@umcg.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HIAA ; 5-hydroxyindolacetic acid ; 5-HT ; 5-hydroxytryptamine ; 5-HTP ; 5- hydroxytryptophan ; AADC ; aromatic L-amino acid decarboxylase ; ADR ; acute dystonic reaction ; BH4 ; tetrahydrobiopterin ; CSF ; cerebrospinal fluid ; DRD ; dopa-responsive dystonia ; dRN ; dorsal raphe nucleus ; DTG ; di-o-tolyguanidine ; DYT ; dystonia ; GCH1 ; GTP cyclohydrolase deficiency 1 ; GP ; globus pallidus ; GPi ; globus pallidus pars interna ; GPe ; globus pallidus pars externa ; HVA ; homovanillic acid ; PKAN ; panthothenate kinase assoc
- 刊名：Neuroscience & Biobehavioral Reviews
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：264-275
- 全文大小：1003 K
文摘
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We examined the role of serotonin in inherited, acquired and idiopathic dystonia.
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Most studies point towards a hypofunction of the serotonergic system in dystonia.
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Serotonergic/dopaminergic imbalances may be an important modulator of dystonia.
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High prevalences of psychiatric co-morbidity may suggest serotonergic dysfunction.
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Influencing serotonin may form a new potential target for therapeutical interventions.