l-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons
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- 作者：Martin Klietza ; b ; &dagger ; ; &Dagger ; ; Ursula Keberb ; &dagger ; ; ¶ ; ; Thomas Carlssonb ; c ; Wei-Hua Chiub ; Gü ; nter U. Hö ; glingerb ; d ; Eberhard Weihea ; Martin K.-H. Schä ; fera ; &dagger ; ; schaefem@staff.uni-marburg.de" class="auth_mail" title="E-mail the corresponding author ; Candan Depboylub ; &dagger ; ; depboylu@med.uni-marburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：6-OHDA ; 6-hydroxydopamine ; AADC ; aromatic amino acid decarboxylase ; AIM ; abnormal involuntary movements ; ANOVA ; Analysis of Variance ; DA ; dopamine ; ISH ; in situ hybridization ; l-DOPA ; l-3 ; 4-Dihydroxyphenylalanine ; LID ; l-DOPA-induced dyskinesia ; mfb ; medial forebrain bundle ; PD ; Parkinson&rsquo ; s disease ; SNpc ; substantia nigra pars compacta ; TH ; tyrosine hydroxylase ; VTA ; ventral tegmental area
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：7 September 2016
- 年：2016
- 卷：331
- 期：Complete
- 页码：120-133
- 全文大小：2519 K
文摘
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Increase of TH mRNA+ and TH protein+ neurons in striatum following dopaminergic denervation in mice.
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Reduced TH mRNA+ but constant TH protein+ neurons in denervated striatum of l-DOPA-treated non-dyskinetic mice (No LID).
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Increase of TH protein+ but constant TH mRNA+ neurons in denervated striatum of dyskinetic mice (LID).
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Similar change of TH mRNA+ neurons in intact striatum following l-DOPA, but unknown effect on TH translation (?).