PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa
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- 作者：Reidar Fossmarka ; b ; reidar.fossmark@ntnu.no" class="auth_mail" title="E-mail the corresponding author ; Shalini Raoa ; shalini.rao@ntnu.no" class="auth_mail" title="E-mail the corresponding author ; Patricia Mjø ; nesa ; c ; patricia.mjones@ntnu.no" class="auth_mail" title="E-mail the corresponding author ; Bjø ; rn Munkvolda ; bjorn.munkvold@ntnu.no" class="auth_mail" title="E-mail the corresponding author ; Arnar Flatberga ; arnar.flatberg@ntnu.no" class="auth_mail" title="E-mail the corresponding author ; Andrea Varrod ; a.varro@liverpool.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Liv Thommesena ; liv.thommesen@ntnu.no" class="auth_mail" title="E-mail the corresponding author ; Kristin G. Nø ; rsetta ; e ; kristin.norsett@ntnu.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：PAI-1 ; plasminogen activator inhibitor 1 ; uPA ; urokinase plasminogen activator ; KO ; knockout ; EMT ; epithelial-to-mesenchymal transition ; PPI ; proton pump inhibitor ; H. pylori ; Helicobacter pylori ; ECL ; enterochromaffin-like ; HK ; H+K+-ATPase beta subunit ; WT ; wild type ; CgA and Chga ; chromogranin A ; HDC ; histidine decarboxylase ; MIAME ; minimum information about a microarray experiment
- 刊名：Peptides
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：79
- 期：Complete
- 页码：83-94
- 全文大小：4031 K
文摘
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PAI-1 influences gastric corpus mucosal organization in hypergastrinemic mice.
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PAI-1 knockout causes exaggerated hypergastrinemia, as well as trophic and architectural changes in gastric corpus mucosa.
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PAI-1 may exert a protective effect in gastric carcinogenesis.