Structural and functional analogies and differences between histidine decarboxylase and aromatic l-amino acid decarboxylase molecular networks: Biomedical implications

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• 作者：Francisca Sanchez-Jimé ; nez^a ; ^b ; ^kika@uma.es ; Almudena Pino-Á ; ngeles^c ; Rocio Rodrí ; guez-Ló ; pez^a ; Marí ; a Morales^a ; José ; Luis Urdiales^a ; ^b
• 关键词：Histamine ; Dopamine ; Serotonin ; Orphan diseases ; Molecular interactions ; Systems pharmacology
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：114
• 期：Complete
• 页码：90-102
• 全文大小：2917 K
• 卷排序：114

文摘

Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. The enzymes share many structural and functional analogies, while their product metabolisms also follow similar patterns that are confluent in some metabolic steps. They are involved in common physiological functions, such as neurotransmission, gastrointestinal track function, immunity, cell growth and cell differentiation. As a consequence, metabolic elements of both BA subfamilies are also co-participants in a long list of human diseases. This review summarizes the analogies and differences in their origin (HDC and DDC) as well as their common pathophysiological scenarios. The major gaps of information are also underlined, as they delay the possibility of holistic approaches that would help personalized medicine and pharmacological initiatives for prevalent and rare diseases.