Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins
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- 作者：Gaspar J. Kitange1 ; kitange.gaspar@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Ann C. Mladek1 ; Mark A. Schroeder1 ; Jenny C. Pokorny1 ; Brett L. Carlson1 ; Yuji Zhang2 ; 4 ; Asha A. Nair2 ; Jeong-Heon Lee3 ; Huihuang Yan2 ; Paul A. Decker2 ; Zhiguo Zhang3 ; Jann N. Sarkaria1
- 关键词：RBBP4 ; temozolomide ; resistance ; MGMT ; glioblastoma
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：22 March 2016
- 年：2016
- 卷：14
- 期：11
- 页码：2587-2598
- 全文大小：3000 K
文摘
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RBBP4 disruption sensitizes GBM cells to temozolomide
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RBBP4 controls temozolomide sensitivity by regulating multiple DNA repair proteins
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RBBP4 regulates the expression of MGMT, RAD51, FIGNL1, and EYA1
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RBBP4 interacts with CBP/p300 to enhance chromatin-mediated gene expression