Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression

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• 作者：Katharina Domschke ; Christa Hohoff ; Lena S. Mortensen ; Tilmann Roehrs ; Jü ; rgen Deckert ; Volker Arolt ; Bernhard T. Baune
• 关键词：Antidepressant treatment ; Major Depression ; Monoamine oxidase A ; Pharmacogenetics ; VNTR
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2008
• 出版时间：1 January 2008
• 年：2008
• 卷：32
• 期：1
• 页码：224-228
• 全文大小：212 K

文摘

The monoamine oxidase A (MAO-A) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of Major Depression.

In the present study, 340 patients with a Major Depressive Episode (f = 194, m = 146; DSM-IV) of Caucasian descent were genotyped for the functional MAO-A VNTR. The clinical response to antidepressive pharmacological treatment was assessed by weekly intra-individual changes of HAM-D-21 scores over six weeks.

The longer MAO-A alleles (3a, 4, 5) conferred a significant risk of slower and less efficient overall response over the course of 6 weeks of antidepressant treatment in patients with Major Depression, with the effect being restricted to female patients (p = 0.028; corrected for multiple testing).

The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression.