Cannabinoid receptor 1 (CNR1

详细信息    查看全文

• 作者：Katharina Domschke ; Udo Dannlowski ; Patricia Ohrmann ; Bruce Lawford ; Jochen Bauer ; Harald Kugel ; Walter Heindel ; Ross Young ; Phillip Morris ; Volker Arolt ; Jü ; rgen Deckert ; Thomas Suslow ; Bernhard
• 关键词：Depression ; Anxiety ; Endocannabinoid system ; CNR1 ; Pharmacogenetic ; Treatment response
• 刊名：European Neuropsychopharmacology
• 出版年：2008
• 出版时间：October 2008
• 年：2008
• 卷：18
• 期：10
• 页码：751-759
• 全文大小：363 K

文摘

The endocannabinoid system has been implicated in the pathogenesis of depression and anxiety, the mediation of antidepressant drug effects in animal models and the neurobiology of emotion processing in healthy volunteers.

Therefore, the impact of cannabinoid receptor 1 gene (CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 Caucasian patients with Major Depression. A subsample of 33 depressed patients was additionally scanned by fMRI under visual presentation of emotional faces.

The CNR1 rs1049353 G allele conferred an increased risk of antidepressant treatment resistance, particularly in female patients with high comorbid anxiety. CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces.

This analysis provides preliminary support for a role of CNR1 gene variation in depression and anxiety, potentially mediated by subcortical hypo-responsiveness to social reward stimuli.