Development and validation of a UHPLC-MS/MS method for simultaneous quantitation the plasma concentration of Sabarubicin and its alcohol metabolite M3 in Chinese small cell lung cancer patients
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- 作者：Yan Zhanga ; Peng Liua ; Ning Lia ; Di Wua ; Yun Fenga ; Yuanyuan Songa ; Yuankai Shia ; ; Xiaohong Hana ; b ; hanxh@cicams.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：NSCLC ; non-small cell lung cancer ; SCLC ; small cell lung cancer ; CFDA ; China Food and Drug Administration ; UHPLC&ndash ; MS/MS ; ultra high performance liquid chromatography&ndash ; tandem mass spectrometry ; IS ; internal standard ; HPLC-grade ; high performance liquid chromatography grade ; ESI ; electrospray ionization ; MRM ; multiple reaction monitoring ; DP ; declustering potential ; EP ; entrance potential ; CXP ; collision cell exit potential ; CE ; collision energy ; CUR ; Curtain gas ; TEM ; turbo-gas temperat
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：1025
- 期：Complete
- 页码：119-125
- 全文大小：1388 K
文摘
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Built a UHPLC–MS/MS method for simultaneous quantification of Sabarubicin and its alcohol metabolite in human plasma.
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Lower limit of quantitation was 2 ng/mL for Sabarubicin and 0.5 ng/mL for M3 with a sample volume of 100 μL.
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Method was proved to be sufficient for pharmacokinetics study in Chinese SCLC patients.