Acidic horseradish peroxidase activity abolishes genotoxicity of common dyes
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- 作者：Barbara S. Janovića ; bjanovic@chem.bg.ac.rs" class="auth_mail" title="E-mail the corresponding author ; biba.janovic@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Andrew R. Collinsb ; Zoran M. Vujčićc ; Miroslava T. Vujčića
- 关键词：DNA damage ; Comet assay ; Horseradish peroxidase a ; Decolorization ; Dye degradation ; DNA interactions
- 刊名：Journal of Hazardous Materials
- 出版年：2017
- 出版时间：5 January 2017
- 年：2017
- 卷：321
- 期：Complete
- 页码：576-585
- 全文大小：3353 K
文摘
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Decolorization of several types of dye by acidic horseradish peroxidase.
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Evaluation of genotoxicity of eight dyes by medium-throughput comet assay in BEAS-2B cell.
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Detection of DNA damage before and after decolorization using basic and modified comet assay.
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OR2 showed increase in FPG-sensitive sites, while AB showed no increase.
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DNA binding studies were investigated by absorption and fluorescence spectroscopy.