Pb nanowires-Au nanoparticles nanostructure decorated reduced graphene oxide were synthesized for the first time. A novel non-enzyme H2O2 sensor was fabricated based rGO-Pb NWs-GNPs by a facile electrodeposition method. The sensor exhibited good catalytic ability to the reduction of H2O2. The study provides a potential platform and practicable approach to fabricate various of non-enzymatic amperometric sensors.