A high fat diet-induced decrease in hippocampal newly-born neurons of male mice is exacerbated by mild psychological stress using a Communication Box

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• 作者：Yusuke Murata^a ; ^{ymurata@fukuoka-u.ac.jp} ; Yukiyasu Narisawa^a ; Rima Shimono^a ; Hiraku Ohmori^a ; Masayoshi Mori^a ; Kenji Ohe^a ; Kazunori Mine^b ; Munechika Enjoji^a
• 关键词：Communication Box ; Depression ; Hippocampal neurogenesis ; High fat diet ; Obesity ; Psychological stress ; Stress vulnerability
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：209
• 期：Complete
• 页码：209-216
• 全文大小：1123 K
• 卷排序：209

文摘

Obese persons are shown to have a high incidence of depression. We investigated the effect of Communication Box on hippocampal neurogenesis. Hippocampal neurogenesis was decreased in high fat diet-induced obese (HFDIO) mice Mild psychological stress induced a further decrease in neurogenesis of HFDIO mice. The decreased neurogenesis contributes to stress vulnerability for obese persons.