Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis
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- 作者：Halima Amhaoula ; Julie Hamaidea ; b ; Daniele Bertoglioa ; Stephanie Nadine Reichela ; Jeroen Verhaeghec ; Elly Geertsd ; Debby Van Damd ; Peter Paul De Deynd ; e ; f ; Samir Kumar-Singhg ; Andrew Katsifish ; Annemie Van Der Lindenb ; Steven Staelensc ; Stefanie Dedeurwaerderea ; stefanie.dedeurwaerdere@uantwerpen.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-D ; three-dimensional ; CA ; cornu ammonis ; CT ; computed tomography ; DG ; dentate gyrus ; DH ; dentate hilus ; GFAP ; glial fibrillary acid protein ; KA ; kainic acid ; KASE ; kainic acid-induced status epilepticus ; MR ; magnetic resonance ; MRI ; magnetic resonance imaging ; OD ; optical density ; PBS ; phosphate buffered saline ; PET ; positron emission tomography ; ROI ; region of interest ; s.c. ; subcutaneous ; SE ; status epilepticus ; SRS ; spontaneous recurrent seizures ; TLE ; temporal lobe epilepsy ; TSPO ; transloc
- 刊名：Neurobiology of Disease
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：82
- 期：Complete
- 页码：526-539
- 全文大小：2217 K
文摘
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TSPO expression in limbic system evolves during epileptogenesis.
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TSPO expression peaks during latent phase.
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Association between TSPO and microglial activation/cell loss
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Association between TSPO and spontaneous recurrent seizures
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TSPO PET successfully detects the evolution of TSPO expression in vivo.