Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction
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- 作者：Lauren Kostena ; Jeroen Verhaeghea ; Robert Verkerkb ; David Thomaea ; d ; Livia De Pickerc ; Leonie wyffelsa ; d ; Annemie Van Eetveldte ; Stefanie Dedeurwaerderee ; Sigrid Stroobantsa ; d ; Steven Staelensa ; steven.staelens@uantwerpen.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：BPnd ; non-displacable binding potential ; CG ; cingulate cortex ; CP ; caudate putamen ; CT ; computed tomography ; Ctrl ; control ; Ctrl-PBO ; placebo-treated control cohort ; Ctrl-NAc ; NAc-treated control cohort ; FOV ; field of view ; GSH ; glutathion ; HC ; hippocampus ; HPLC ; high-pressure liquid chromatography ; IDO ; indoleamine-2 ; 3-deoxygenase ; IHC ; immunohistochemistry ; IOD ; intrinsic optical density ; i.p. ; intraperitoneal ; i.v. ; intravenous ; KA ; kynurenic acid ; KAT ; kynurenine amino transferase ; KYN ; kynu
- 刊名：Psychiatry Research: Neuroimaging
- 出版年：2016
- 出版时间：28 February 2016
- 年：2016
- 卷：248
- 期：Complete
- 页码：1-11
- 全文大小：5442 K
文摘
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The first longitudinal multiprobe μPET study in a NMDAR hypofunction rat model.
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Chronic high glutamate tends to upregulate mGluR5 expression or shift the affinity.
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Microglial activation appears to amplify already increased glutamate levels.
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TRYCAT pathway overactivation contributes to the pathology.
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Targeting mGluR5 receptors for antipsychotics development remains promising.