Nongenomic effects of 1α,25-dihydroxyvitamin D₃ on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

详细信息    查看全文

• 作者：Yoshihisa Hirota^a ; ^b ; ¹ ; ^{hirotay@shibaura-it.ac.jp} ; Kimie Nakagawa^b ; ¹ ; Shino Mimatsu^b ; ¹ ; Natsumi Sawada^b ; Toshiyuki Sakaki^c ; Noboru Kubodera^d ; Maya Kamao^b ; Naoko Tsugawa^b ; Yoshitomo Suhara^e ; Toshio Okano^b ; ^{t-okano@kobepharma-u.ac.jp}
• 关键词：Vitamin D ; CYP27B1 ; VDR ; Knockout mice ; Bone remodeling ; Genomic action
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：359-365
• 全文大小：2463 K
• 卷排序：483

文摘

We produced Cyp27b1−/− mice and analyzed their phenotypes. Vdr−/− mice exhibited alopecia and Cyp27b1−/− mice exhibited cartilage dysplasia. Maintenance of the hair cycle is associated with 25D3 via Vdr. 1α,25D3 controls chondrocyte proliferation and differentiation independent of Vdr.