A novel 5HT3 antagonist 4i (N-(3-chloro-2-methylphenyl)quinoxalin-2-carboxamide) prevents diabetes-induced depressive phenotypes in mice: Modulation of serotonergic system
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- 作者：Deepali Guptaa ; deepaligupta2010@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Devadoss Thangarajb ; Mahesh Radhakrishnanc
- 关键词：Diabetes ; Depressive phenotypes ; 5HT3 receptor antagonist ; Forced swim test ; Open field test ; Serotonin
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：297
- 期：Complete
- 页码：41-50
- 全文大小：1861 K
文摘
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STZ-induced diabetes resulted in the significant depressive phenotypes in mice.
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4i, a novel 5HT3 receptor antagonist prevented diabetes-induced depressive phenotypes in mice.
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4i normalized reduced serotonin levels in mid brain, prefrontal cortex and cerebellum.
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mCPBG, a selective 5HT3 receptor agonist abolished 4i responses in diabetic mice.
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Antidepressant effect of 4i may be mediated by 5HT3 receptor antagonism and increase in serotonin levels.