Maternal 25-hydroxyvitamin D level and the occurrence of neural tube defects in Tunisia

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• 作者：Kaouther Nasri^a ; ^b ; ^{nasrikaouther512@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mohamed K. Ben Fradj^c ; Moncef Feki^c ; Naziha Kaabechi^c ; Mariem Sahraoui^b ; Aida Masmoudi^b ; Raja Marrakchi^d ; Soumeya S. Gaigi^b
• 关键词：Neural tube defects ; Pregnancy ; Vitamin D deficiency ; Vitamin D status
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：134
• 期：2
• 页码：131-134
• 全文大小：237 K

文摘

To determine whether low vitamin D levels in pregnant women are associated with the occurrence of neural tube defects (NTDs) in Tunisia.

Methods

In a prospective study, pregnant women were recruited at a center in Tunis between January 1, 2012, and December 30, 2013. Women carrying a fetus with a severe NTD were recruited before elective termination. Matched, healthy pregnancy women were enrolled into a control group. Plasma levels of 25-hydroxyvitamin D were measured by a competitive chemiluminescence immunoassay.

Results

Overall, 68 women formed the NTD group and 64 the control group. The mean maternal vitamin D level was significantly lower in the NTD group (20.65 ± 10.25 nmol/L) than in the control group (28.30 ± 13.82 nmol/L; P < 0.001). Vitamin D deficiency was recorded for 53 (78%) women in the NTD group and 39 (61%) in the control group. Vitamin D insufficiency was recorded for 15 (22%) women in the NTD group and 20 (31%) in the control group. Vitamin D sufficiency was found only in the control group (n = 5 [8%]; P < 0.001).

Conclusion

The findings confirm an association between a decreased vitamin D level in pregnant women and the risk of fetal NTDs.