The human cathelicidin LL-37 ‿A pore-forming antibacterial peptide and host-cell modulator
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- 作者：Daniela Xhindoli ; Sabrina Pacor ; Monica Benincasa ; Marco Scocchi ; Renato Gennaro ; Alessandro Tossi ; atossi@units.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cathelicidin ; LL-37 ; hCAP-18 ; CRAMP ; Host defence peptide ; Antimicrobial peptide ; Innate immunity
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：1858
- 期：3
- 页码：546-566
- 全文大小：1532 K
文摘
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Cathelicidins are a conserved component of innate immunity in vertebrates.
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LL-37, the human CATHELICIDIN peptide, has multiple roles in host defence.
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It inactivates bacteria by forming discreet membrane lesions (pore-forming).
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It modulates host cell responses via membrane-mediated receptor interactions.
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These capacities depend on its adoption of a helical oligomeric structure.
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Orthologues from other eutherian species have evolved different modes of action.