Human β-defensin-3 alleviates the progression of atherosclerosis accelerated by Porphyromonas gingivalis lipopolysaccharide
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- 作者：Lili Lia ; b ; Tianying Biana ; b ; Jinglu Lyua ; b ; Di Cuia ; b ; Lang Leia ; c ; Fuhua Yana ; b ; fhyan2005@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human β-defensin-3 ; Atherosclerosis ; Porphyromonas gingivalis ; Lipopolysaccharide ; Periodontitis
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：204-213
- 全文大小：2519 K
文摘
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Verifying that the progression of AS can be accelerated by LPS from P.gingivalis, which is a periodontal pathogen.
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Serving an initial view of hBD3 on the progression of AS aggravated by P.gingivalis LPS.
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Demonstrating that hBD3 decreases the expression of IL-6 and MCP-1 in the aortas of mice treated with P. gingivalis LPS.
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Showing that hBD3 reduces the cytokine expression in macrophages via the MAPK and NF-κB signaling pathways.
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Providing direct evidence about the role of hBD3 in vessels, since very limited evidence has been find previously.