A Changing Pattern in the Association of Oral Contraceptives and the Different Groups of Congenital Limb Deficiencies
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- 作者：Czeizel ; Andrew E. ; Kodaj ; Imre
- 关键词：contraceptive pills ; congenital limb deficiency ; terminal transverse defects
- 刊名：Contraception
- 出版年：1995
- 出版时间：January, 1995
- 年：1995
- 卷：51
- 期：1
- 页码：19-24
- 全文大小：594 K
文摘
A case-control study on different groups of isolated congenital limb deficiency was performed in a ten-year population-based and revised Hungarian data set. A higher rate of one contraceptive pill type with relatively high dose (ethynodiol diacetate 1.0 mg + ethinyloestradiol 0.05 mg) used in the periconceptional period was found in the mothers of cases with terminal transverse defect (adjusted relative odds 1.9 with 95 % confidence interval of 1.1-3.4). This risk is minimised by the use of recent low-dose pills.