Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID
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- 作者：Anja Schadea ; Claudia Wallisera ; Martin Wista ; Jennifer Haasa ; Petra Vattera ; Johann M. Krausb ; Davide Filingeric ; 1 ; George Havenithc ; Hans A. Kestlerb ; Joshua D. Milnerd ; Peter Gierschika ; peter.gierschik@uni-ulm.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：PLC ; inositol-phospholipid-specific phospholipase C ; SH2 ; Src homology domain 2 ; SH3 ; Src homology domain 3 ; PH ; pleckstrin homology domain ; spPH ; split PH domain ; PCI ; phospholipase C inhibitor peptide ; Rac ; Ras-related C3 botulinum toxin substrate ; BCR ; B cell receptor ; SA ; specific array ; PLAID ; PLCγ2-associated antibody deficiency and immune dysregulation ; TRP ; transient receptor potential ; PtdIns ; phosphatidylinositol ; PtdIns(4)P ; phosphatidylinositol 4-phosphate ; PtdIns(4 ; 5)P2 ; phosphatidy
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1237-1251
- 全文大小：2023 K
文摘
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Custom assemblies used to study human PLAID mutant PLCγ2 functions in intact cells.
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Marked activation of the two human PLAID PLCγ2 mutants by only slight cooling
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Mechanism(s) of activation distinct from loss of SH-region-mediated autoinhibition
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Novel PLCγ2 regulatory role of its spPH domain
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New mechanism of PLCγ2 activation