Nucleotide sugar transporters of the Golgi apparatus

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• 作者：Berninsone ; Patricia M ; Hirschberg ; Carlos B
• 关键词：ER ; endoplasmic reticulum ; LAD II ; leukocyte adhesion deficiency type II syndrome ; MDCK ; Madin&ndash ; Darby canine kidney ; NST ; nucleotide sugar transporter
• 刊名：Current Opinion in Structural Biology
• 出版年：2000
• 出版时间：October 1, 2000
• 年：2000
• 卷：10
• 期：5
• 页码：542-547
• 全文大小：166 K

文摘

Glycosylation, sulfation and phosphorylation of proteins, proteoglycans and lipids occur in the lumen of the Golgi apparatus. The nucleotide substrates of these reactions must be first transported from the cytosol into the Golgi lumen by specific transporters. The topology and structure of these hydrophobic, multi-transmembrane-spanning proteins are beginning to be understood.