Suppression of proatherogenic leukocyte interactions by MCS-18 - Impact on advanced atherosclerosis in ApoE-deficient mice
详细信息 查看全文
- 作者：Constanze Kuehna ; Miyuki Tauchia ; Christian Stumpfa ; Christoph Danielb ; Tobias Bä ; uerlec ; Marc Schwarzc ; Franz Kerekd ; Alexander Steinkasserere ; Elisabeth Zinsere ; Stephan Achenbacha ; Barbara Dietela ; Barbara.Dietel@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; ApoE-deficient mice ; MCS-18 ; Adhesion ; Dendritic cells ; HUVEC ; Inflammation
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：101-110
- 全文大小：3423 K
文摘
- •
The herbal product MCS-18 reduces plaque burden in advanced murine atherosclerosis.
- •
MCS-18 promotes an increased plaque stability of advanced lesions in ApoE −/− mice.
- •
MCS-18 decreases endothelial expression of ICAM-1 and intracellular NF-κB-p65.
- •
MCS-18 reduces human DC migration and expression of CD209 and CCR7 by DCs.
- •
MCS-18 suppresses human DC adhesion to an endothelial cell monolayer.