Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice
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- 作者：Nemanja Vujica ; Stefanie Schlagera ; Thomas O. Eichmannb ; Corina T. Madreiter-Sokolowskia ; Madeleine Goeritzera ; Silvia Rainera ; Silvia Schauerc ; Angelika Rosenbergerd ; Albert Woelflerd ; Prakash Doddapattara ; 1 ; Robert Zimmermannb ; Gerald Hoeflerc ; Achim Lassb ; Wolfgang F. Graiera ; Branislav Radovica ; Dagmar Kratkya ; dagmar.kratky@medunigraz.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apolipoprotein E-deficient mice ; Atherosclerosis ; Cannabinoid 2 receptor ; Endocannabinoid signaling ; 2-Arachidonoyl glycerol
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：244
- 期：Complete
- 页码：9-21
- 全文大小：5052 K
文摘
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Plasma, aortic, and macrophage 2-AG levels are increased in ApoE/MGL-DKO mice.
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Desensitization of CB1R but not CB2R occurs in DKO mice.
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DKO mice develop less vulnerable atherosclerotic lesions.
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CB2R antagonist treatment reverses plaque phenotype in DKO mice.