Motor cortex plasticity can indicate vulnerability to motor fluctuation and high L-DOPA need in drug-naïve Parkinson's disease

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• 作者：Asha Kishore^a ; ^{asha@sctimst.ac.in} ; Praveen James^a ; Syam Krishnan^a ; Lydia Yahia-Cherif^b ; ^c ; Sabine Meunier^b ; Traian Popa^b
• 关键词：Parkinson's disease ; Motor cortex ; Plasticity ; Cerebellum ; Transcranial magnetic stimulation
• 刊名：Parkinsonism & Related Disorders
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：35
• 期：Complete
• 页码：55-62
• 全文大小：698 K
• 卷排序：35

文摘

Impaired motor cortex plasticity is not invariable in untreated Parkinson's disease. Plasticity level of motor cortex may not contribute to early motor signs. Milder motor deficits linked to effective cerebellar modulation of motor plasticity. Motor cortex plasticity in denovo state can predict motor fluctuation at 4 years.