The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development
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- 作者：Yewei Ji1 ; 5 ; 6 ; Hana Kim2 ; 5 ; 6 ; Liu Yang1 ; Haibo Sha1 ; 7 ; Christopher A. Roman3 ; Qiaoming Long4 ; Ling Qi1 ; 2 ; 6 ; 8 ; lingq@med.umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：endoplasmic reticulum-associated degradation ; Sel1L ; Hrd1 ; B cell development ; pre-B cell receptor ; large pre-B cells
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：6 September 2016
- 年：2016
- 卷：16
- 期：10
- 页码：2630-2640
- 全文大小：3614 K
文摘
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ERAD deficiency blocks the transition from large pre-B cells to small pre-B cells
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ERAD manages a B cell developmental checkpoint by attenuating pre-BCR signaling
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The pre-BCR complex is an endogenous Sel1L-Hrd1 ERAD substrate in B cells
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Pre-BCR degradation by the Sel1L-Hrd1 complex requires the ER chaperone BiP