LC-MS/MS assay for the quantitation of the tyrosine kinase inhibitor neratinib in human plasma
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文摘
Neratinib is an orally available TKI targeting EGRR and HER2 in clinical development. An LC–MS/MS assay from 2 to 1000 ng/mL in 0.1 mL plasma was developed and validated. Signal degradation was observed but corrected with isotopic internal standard. Assay is being utilized to support neratinib combination clinical studies.

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