Dual pH and oxidation responsive poly(ether-urethane) nanoparticles were developed.
Injectable supramolecular hydrogels based on poly(ether-urethane) nanoparticles and α-CD were prepared.
The hydrogels displayed a pH-induced reversible sol–gel transition and an oxidation-triggered degradation behavior.
The hydrogels showed promise for co-encapsulation and triggered release of hydrophobic and hydrophilic drugs.