An injectable, dual pH and oxidation-responsive supramolecular hydrogel for controlled dual drug delivery
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- 作者：Xinfeng Chenga ; b ; Yong Jinc ; d ; jinyong@cioc.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Tongbing Suna ; b ; Rui Qia ; b ; Hanping Lic ; d ; Wuhou Fanc ; d
- 关键词：Supramolecular hydrogel ; Polyurethane ; pH-responsive ; Oxidation-responsive ; Dual drug delivery
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：44-52
- 全文大小：2191 K
文摘
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Dual pH and oxidation responsive poly(ether-urethane) nanoparticles were developed.
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Injectable supramolecular hydrogels based on poly(ether-urethane) nanoparticles and α-CD were prepared.
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The hydrogels displayed a pH-induced reversible sol–gel transition and an oxidation-triggered degradation behavior.
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The hydrogels showed promise for co-encapsulation and triggered release of hydrophobic and hydrophilic drugs.