mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety

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• 作者：Yuichi Deguchi¹ ; ^{y-deguchi@nagasaki-u.ac.jp} ; Masaya Harada¹ ; Ryota Shinohara¹ ; Michael Lazarus² ; Yoan Cherasse² ; Yoshihiro Urade² ; Daisuke Yamada³ ; Masayuki Sekiguchi³ ; Dai Watanabe⁴ ; Tomoyuki Furuyashiki¹ ; Shuh Narumiya¹ ; ⁵ ; ^{snaru@mfour.med.kyoto-u.ac.jp}
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2405-2417
• 全文大小：4350 K
• 卷排序：17

文摘

Social-isolation-induced anxiety requires mDia, an actin nucleator, in NAc neurons mDia induces actin filaments around edges of the synaptic cleft in presynaptic terminals mDia- and ROCK-dependent actomyosin in presynaptic terminals induces contraction mDia-mediated presynaptic contraction reduces GABAergic synaptic efficacy for anxiety