- 作者：Mohammadreza Bordbar ; MD ; Sezaneh Haghpanah ; MD ; Abdolreza Afrasiabi ; PhD ; Javad Dehbozorgian ; PhD ; Mehran Karimi ; MD ; karimim@sums.ac.ir
- 关键词：¦Â-thalassemia intermedia ; ¦Â-thalassemia major ; Genotype ; Lipid profiles
- 刊名：Journal of Clinical Lipidology
- 出版年：2012
- 出版时间：March-April, 2012
- 年：2012
- 卷：6
- 期：2
- 页码：108-113
- 全文大小：122 K
ass=""h4"">Background
Beta-thalassemia is commonly associated with lipid abnormalities. The aim of this study was to search for links between these lipid alterations and different types of ¦Â-thalassemia mutations.ass=""h4"">Methods
The study, conducted from 2009 to 2010, included 100 patients with thalassemia major (TM) and 100 with thalassemia intermedia (TI). The control group was selected from 100 age- and sex-matched healthy individuals with normal hematologic indices. Serum lipid profiles, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), were determined and their relationship with different covariates, including different ¦Â-globin gene mutations, was analyzed.
ass=""h4"">Results
Patients with TI had significantly lower values for TC, LDL-C, HDL-C, and LDL-C/HDL-C ratio compared with TM patients and controls (P < .001). TG was greater in TM compared with TI patients (P?= .001) and healthy individuals (P?= .007). Hemoglobin was positively associated with TC (P < .001), LDL-C (P?= .004), and HDL-C (P?= .01) in TM patients. Splenectomy correlated with greater TC (P?= .006) and LDL-C (P?= .01) in TI patients, but only with greater LDL-C in TM patients (P?= .02). The average amounts of TC and LDL-C were lower in persons with the ¦Â0/¦Â0 mutation compared with the ¦Â+/¦Â+ group.
ass=""h4"">Conclusion
Lower amounts of TG, TC, LDL-C, and HDL-C were seen in TI patients compared with TM patients and healthy individuals. The severity of the genotype (ie, ¦Â0 type mutations compared with ¦Â+ type mutations) affected the degree of reduction in serum lipids.