Therapeutic effects of calcium & vitamin D supplementation in women with PCOS

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• 作者：Raziah dehghani Firouzabadi^a ; ^{dr_firouzabadi@ssu.ac.ir} ; Abbas Aflatoonian^a ; ^{abbas_aflatoonian@yahoo.com} ; Seyedehzalfa Modarresi^b ; ^{dr.modarres@gmail.com} ; Leila Sekhavat^c ; ^{sekhavat@ssu.ac.ir} ; ^{lsekhavat@yahoo.com} ; Somayeh MohammadTaheri^d ; ^{dr.smtaheri@gmail.com}
• 关键词：Polycystic ovary syndrome ; Calcium ; Vitamin D ; Metformin
• 刊名：Complementary Therapies in Clinical Practice
• 出版年：2012
• 出版时间：May, 2012
• 年：2012
• 卷：18
• 期：2
• 页码：85-88
• 全文大小：124 K

文摘

Objective

To evaluate the efficacy of calcium & vitamin D supplementation in infertile women suffering from polycystic ovary syndrome (PCOS), and to assess levels of 25-hydroxy vitamin D in these patients.

Methods

In a case control study, 100 infertile PCOS women based on a randomly divided into two groups. Group I (n?=?50) were treated with metformin 1500?mg/day, and group II (n?=?50) treated with metformin 1500?mg/day plus Calcium 1000?mg/day and Vitamin D 100000?IU/month for 6 months. Patients were followed by transvaginal sonography at first, 3 and 6 months later for evaluating dominant follicle.

BMI, menstrual regularity, follicle diameter, pregnancy, serum 25-OH-vitamin D level were matured and compared in two groups.

Results

BMI decreased almost significantly (25.49?¡À?1.88 vs 26.28?¡À?2.15, p: 0.054) in group II. A better improvement was gained in regulating menstrual abnormalities (70 % vs 58 % , p: 0.211), follicle maturation (28 % vs 22 % , p: 0.698), and infertility (18 % vs 12 % , p: 0.401) in group II compared with group I, but these results were not statistically significant. Eighty three percent of all the PCOS patients showed vitamin D deficiency while 35 % were severely deficient. The serum 25-OH-vitamin D mean levels were 13.38?¡À?6.48?ng/ml. Vitamin D deficiency was recompensed in 74 % of the PCOS patients who had taken calcium & vitamin D supplementation. There was no correlation between BMI and 25-OH-VD before and after the treatment (p?¡Ý?.01).

Conclusion

This study showed the positive effects of calcium & vitamin D supplementation on weight loss, follicle maturation, menstrual regularity, and improvement of hyperandrogenism, in infertile women with PCOS.