Development and validation of a LC-MS/MS method for quantitative analysis of uraemic toxins p-cresol sulphate and indoxyl sulphate in saliva
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- 作者：Joanna Giebułtowicz ; joanna.giebultowicz@wum.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Natalia Korytowska ; Bartłomiej Sankowski ; Piotr Wroczyński
- 关键词：DHEA ; Dehydroepiandrosterone ; EMA ; European Medicines Agency ; FDA ; US Food and Drug Administration ; IQR ; Interquartile range ; IS ; Indoxyl sulphate ; IS-d4 ; Indoxyl sulphate-D4 ; LC-MS/MS ; Liquid chromatography coupled to mass spectrometry ; pCS ; p-Cresol sulphate ; pCS-d7 ; p-Cresol sulphate-D7 ; QC ; Quality control ; RSD ; Relative standard deviation ; SD ; Standard deviation ; sIgA ; Secretory immunoglobulin A
- 刊名：Talanta
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：150
- 期：Complete
- 页码：593-598
- 全文大小：550 K
文摘
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Novel LC-MS/MS method for the determination of uraemic toxins in saliva was created.
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The analysed validation requirements were fulfilled.
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The method was applied for the determination of toxins in the saliva of healthy people.
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No influence of salivary flow nor type of swab was detected.
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Saliva can be considered as an alternative to blood in monitoring toxin levels.