Human DHRS7, promising enzyme in metabolism of steroids and retinoids?
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- 作者：Hana &Scaron ; tambergová ; a ; hana.stambergova@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Lucie Zemanová ; a ; zemanol9@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Tereza Lundová ; a ; lundovat@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Beata Malčeková ; a ; malcekob@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Adam Skarkaa ; skara3aa@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Miroslav &Scaron ; afrb ; safrM@lfhk.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Vladimí ; r Wsó ; la ; vladimir.wsol@faf.cuni.cz" class="auth_mail" title="E-mail the corresponding author
- 关键词：DHRS7 ; dehydrogenase/reductase (SDR family) member 7 ; DHRS7B ; dehydrogenase/reductase (SDR family) member 7B ; DHRS7C ; dehydrogenase/reductase (SDR family) member 7C ; SDR ; short-chain dehydrogenase/reductase ; AKR ; aldo/ketoreductase ; 11β-HSD1 ; 11β-hydroxysteroid dehydrogenase 1 ; ER ; endoplasmic reticulum ; 17β-HSD ; 17β-hydroxysteroid dehydrogenase ; RDH ; retinol dehydrogenase
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：155
- 期：part_PA
- 页码：112-119
- 全文大小：1075 K
文摘
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Amino acid sequence of DHRS7 is highly conserved in diverse species.
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DHRS7 participates in the reductive metabolism of steroids and retinoids.
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DHRS7 catalyzes reduction of several toxic compounds harmful to human health.
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DHRS7 expression patterns were determined at both the mRNA and the protein levels.