SDHC mutation causes complex II deficiency-dependent oxidative stress in female reproductive organs, not male.
The oxidative stress causes ovarian hemangiomas leading to abnormal follicle maturation.
The oxidative stress does not affect spermatogenesis and early embryogenesis.
The oxidative stress causes placental angiodysplasia and inflammation.
The oxidative stress causes embryopathy and developmental arrest with excessive apoptosis.