Methylmercury alters glutathione homeostasis by inhibiting glutaredoxin 1 and enhancing glutathione biosynthesis in cultured human astrocytoma cells
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- 作者：Stephan Robitaillea ; Ryan J. Maillouxb ; Hing Man Chana ; laurie.chan@uottawa.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：MeHg ; Methylmercury ; iHg ; inorganic mercury ; GSH ; reduced glutathione ; GSSG ; glutathione disulfide ; Grx1 ; glutaredoxin 1 ; Gpx1 ; glutathione peroxidase 1 ; Nrf2 ; Nuclear factor (erythroid-derived 2)-like 2 ; GS ; glutathione synthetase ; SdhC ; succinate dehydrogenase subunit C ; Ndusf1 ; NADH ; ubiquinone oxidoreductase core subunit S1
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：256
- 期：Complete
- 页码：1-10
- 全文大小：1291 K
文摘
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MeHg disrupts glutathione homeostasis and intracellular redox state of cultured human astrocytoma cells.
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Exposure to MeHg results in the accumulation of cellular GSSG which increases the redox potential of GSH/GSSG.
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MeHg directly interferes with glutaredoxin-1 (Grx1) activity prolonging protein S-glutathionylation.