Development of a symptomatic intracranial meningioma in a male-to-female transsexual after initiation of hormone therapy

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• 作者：Amy R. deIpolyi ; Seunggu J. Han ; Andrew T. Parsa
• 关键词：Meningioma ; Sex hormone ; Transsexual
• 刊名：Journal of Clinical Neuroscience
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：17
• 期：10
• 页码：1324-1326
• 全文大小：673 K

文摘

Transsexual patients are routinely treated with sex hormone therapy, which may be a risk factor for meningiomas, although the data are largely inconclusive. Here we describe a male-to-female transsexual patient treated with estradiol patches, who developed an occipital meningioma causing generalized seizures. This is the second report of a male-to-female transsexual patient who developed a symptomatic meningioma after sex hormone treatment, adding to the growing evidence that sex hormones contribute to the pathogenesis of meningiomas. Meningiomas may therefore complicate hormone therapy and sex hormones may be contraindicated in transsexual candidates with meningiomas identified upon screening.