Association of retinol binding protein 4 with risk of gestational diabetes

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• 作者：Dejene F. Abetew^a ; ^{Dejene.Abetew@swedish.org} ; Chunfang Qiu^a ; Neway G. Fida^a ; ^b ; Michal Dishi^a ; Karin Hevner^a ; Michelle A. Williams^a ; ^c ; Daniel A. Enquobahrie^a ; ^b
• 关键词：Retinol binding protein 4 ; Gestational diabetes ; Pregnancy ; Maternal age
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：99
• 期：1
• 页码：48-53
• 全文大小：293 K

文摘

Aim

We investigated association of maternal retinol binding protein 4 (RBP4) with risk of gestational diabetes (GDM).

Methods

GDM cases (N = 173) and controls (N = 187) were selected from among participants of a cohort study of risk factors of pregnancy complications. Early pregnancy (16 weeks on average) serum RBP4 concentration was measured using an ELISA-based immunoassay. Logistic regression was used to estimate unadjusted and adjusted odds ratios (ORs/aORs) and 95 % confidence intervals (95 % CI).

Results

Mean serum RBP4 was significantly higher among GDM cases compared with controls (47.1 vs. 41.1 ¦Ìg/ml, respectively; p-value <0.05). Participants in the highest quartile for serum RBP4 had a 1.89-fold higher risk of GDM compared with participants in the lowest quartile (95 % CI: 1.05-3.43). However, this relationship did not reach statistical significance after adjustment for confounders (aOR: 1.54; 95 % CI: 0.82-2.90). Women who were ¡Ý35 years old and who had high RBP4 (¡Ý38.3 ¦Ìg/ml, the median) had a 2.31-fold higher risk of GDM compared with women who were <35 years old and had low RBP4 (<38.3 ¦Ìg/ml) (aOR: 2.31; 95 % CI: 1.26-4.23; p-value for interaction = 0.021).

Conclusion

Overall, there is modest evidence of a positive association of early pregnancy elevated RBP4 concentration with increased GDM risk, particularly among women with advanced age.