Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry
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- 作者：Nicholas J. Brandon nick.brandon@azneuro.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DISC1 ; Disrupted in Schizophrenia 1 ; PDE4 ; phosphodiesterase type 4 ; NDE1 ; nuclear distribution element 1 ; NDEL1 ; NDE-like 1 ; iPS ; induced pluripotent stem cells
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：28
- 期：7
- 页码：749-752
- 全文大小：308 K
文摘
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DISC1 and PDE4 are part of a dynamic signaling complex critical in molecular psychiatry.
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Miles Houslay laboratory were critical for elaborating the details and function of this protein complex.
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Therapeutic value of this complex still to be realized