Cloning of the promoter of NDE1, a gene implicated in psychiatric and neurodevelopmental disorders through copy number variation
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- 作者：N.J. Bradshaw ; nicholas.bradshaw@hhu.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNV ; copy number variation ; NDE1 ; Nuclear Distribution Element 1 ; NDEL1 ; NDE-Like 1 ; UTR ; untranslated region
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：324
- 期：Complete
- 页码：262-270
- 全文大小：1319 K
文摘
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The complex promoter system of the neurodevelopmental gene NDE1 is cloned.
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This gene is implicated in major mental illness through copy number variation.
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In neuroblastoma cells, one NDE1 transcript is predominantly expressed.
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The importance of the 5′ UTR of this transcript is determined.
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These will facilitate the study of NDE1 duplication in major mental illness.