- 作者：Carmen Llá ; cer ; Martine Delannes ; Mathieu Minsat ; Eberhard Stoeckle ; Laurent Votron ; Pierre Martel ; Paul Bonnevialle ; Binh Nguyen Bui ; Christine Chevreau ; Guy Kantor et al.
- 刊名：Radiotherapy and Oncology
- 出版年：2006
- 出版时间：January 2006
- 年：2006
- 卷：78
- 期：1
- 页码：10-16
- 全文大小：99 K
Background and purposeTo evaluate intraoperative brachytherapy in the management of soft tissue sarcomas involving neurovascular structures, its impact on local control and complications.Patients and methods
Between 01/1989 and 12/2002, 98 patients received an intraoperative implant in conjunction with conservative surgery. Brachytherapy was part of the initial treatment (79 cases) or performed in recurrent disease (19 cases). We studied primary sarcomas involving neurovascular structures treated with conservative surgery and intraoperative brachytherapy (n=6) or intraoperative brachytherapy and external irradiation (n=73). Conservative surgery was performed as first treatment (51 cases), after chemotherapy (21 cases) and after primary external radiation (seven cases). Brachytherapy was performed according to Paris system rules. Patients were loaded with Iridium 192 (64 cases) or connected to a Microselectron PDR (15 cases). Mean dose given by brachytherapy was 20 Gy. Mean dose given of external radiotherapy was 46 Gy.
Results
With a median follow-up of 58 months, 5-year actuarial survival was 69 % and local free disease at 5 years was 90 % . Acute side-effects occurred in 22/79 requiring surgical repair in 10 patients. Late side-effects occurred in 35/79. No patient required amputation for complications. Prognostic factors were studied for the occurrence of acute and late side-effects and local control.
Conclusions
Intraoperative brachytherapy is efficient with excellent local control rates in soft tissue sarcomas presenting with neurovascular involvement and offers an acceptable conservative option.