- 作者：Anne Ducassou&lowast ; ; ; anned40@hotmail.com ; Isabelle David M.D.&lowast ; ; Thomas Filleron&dagger ; ; Michel Rives M.D.&lowast ; ; Jacques Bonnet Ph.D.&lowast ; ; Martine Delannes M.D.&lowast ;
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2011
- 出版时间：1 November 2011
- 年：2011
- 卷：81
- 期：3
- 页码：726-731
- 全文大小：162 K
Purpose
Skin cancer is the most common malignancy in white populations. We evaluated the local cure rate and cosmetic outcome of patients with basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) of the face treated with low¨Cdose rate brachytherapy.Methods and Materials
Between February 1990 and May 2000, 147 facial carcinomas in 132 patients were treated by 192Ir wire implantation. Side effects of brachytherapy were noted. Follow-up was 2 years or more. Locoregional recurrence-free survival (LRFS) and overall survival were recorded. Group A included patients treated by primary brachytherapy, and Group B included those treated after recurrence.
Results
A total of 121 carcinomas were BCCs (82.3 % ) and 26 were SCCs (17.7 % ); the median tumor size was 10 mm. Of the tumors, 86 (58.5 % ) were in men and 61 (41.5 % ) were in women; the median age was 71 years. Group A comprised 116 lesions (78.9 % ), and Group B, 31 (21.1 % ). There were 17 relapses (11.6 % ) after a median follow-up of 72 months: 12 local, 4 nodal, and 1 local and nodal. Locoregional-free survival was 96.6 % at 2 years and 87.3 % at 5 years. Five-year LRFS was 82.6 % in men and 93.3 % in women (p = 0.027). After adjustment for gender, LRFS was better after primary treatment than after recurrence (hasard ratio HR, 2.91; 95 % confidence interval, 1.06?.03; p?= 0.039). Five-year LRFS was 90.4 % for BCC and 70.8 % for SCC (p = 0.03). There were no Grade 3 complications.
Conclusions
Low¨Cdose rate brachytherapy offers good local control and cosmetic outcome in patients with periorificial skin carcinomas, with no Grade 3 complications. Brchytherapy is more efficient when used as primary treatment.