Antiprotozoal drug nitazoxanide enhances parasitemia, tissue lesions and mortality caused by Trypanosoma cruzi in murine model

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• 作者：Juan Salvador Valle-Reyes^a ; ^b ; Valery Melnikov^a ; ^{melnik@ucol.mx} ; Oxana Dobrovinskaya^b ; Alejandrina Rodriguez-Herná ; ndez^a ; Cristina Wookee-Zea^a ; Ví ; ctor Pimientel-Rodrigez^a ; Gabriela Rueda-Valdovinos^a ; Ivá ; n Delgado-Enciso^a ; Uriel A. Ló ; pez-Lemus^a ; ^c ; Francisco Espinoza-Gó ; mez^a
• 关键词：Trypanosoma cruzy ; Nitazoxanide ; Mortality
• 刊名：Experimental Parasitology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：172
• 期：Complete
• 页码：44-50
• 全文大小：1530 K
• 卷排序：172

文摘

Oral Nitazoxanide caused high mortality in acute T.cruzi infection in mice. High dose nitazoxanide didn't cause mortality nor tissues damage in healthy mice. Both, parasitemia and tissue damage were higher in nitazoxanide treated animals. Parasitemia and tissues damage are directly related to nitazoxanide dose. Nifurtimox and nitozaxonide combination was less effective than nifurtimox only.